■渡邊　源市：米国留学中の仕事について。

がん細胞の細胞周期が正常細胞よりも早くなるメカニズムについて、培養細胞を用いた細胞内シグナル伝達（MAPキナーゼ系）、転写因子の動態について主に研究を進めた。

1: Lee RJ, Albanese C, Fu M, D'Amico M, Lin B, Watanabe G, Haines GK 3rd, Siegel PM, Hung MC, Yarden Y, Horowitz JM, Muller WJ, Pestell RG. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol. 2000 Jan;20(2):672-83. PMID: 10611246 [PubMed - indexed for MEDLINE]

2: Albanese C, D'Amico M, Reutens AT, Fu M, Watanabe G, Lee RJ, Kitsis RN, Henglein B, Avantaggiati M, Somasundaram K, Thimmapaya B, Pestell RG. Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis. J Biol Chem. 1999 Nov 26;274(48):34186-95. PMID: 10567390 [PubMed - indexed for MEDLINE]

3: Pena P, Reutens AT, Albanese C, D'Amico M, Watanabe G, Donner A, Shu IW, Williams T, Pestell RG. Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. Mol Endocrinol. 1999 Aug;13(8):1402-16. PMID: 10446912 [PubMed - indexed for MEDLINE]

4: Ashton AW, Watanabe G, Albanese C, Harrington EO, Ware JA, Pestell RG. Protein kinase Cdelta inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1). J Biol Chem. 1999 Jul 23;274(30):20805-11. PMID: 10409620 [PubMed - indexed for MEDLINE]

5: Lee RJ, Albanese C, Stenger RJ, Watanabe G, Inghirami G, Haines GK 3rd, Webster M, Muller WJ, Brugge JS, Davis RJ, Pestell RG. pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. J Biol Chem. 1999 Mar 12;274(11):7341-50. PMID: 10066798 [PubMed - indexed for MEDLINE]

6: Galbiati F, Volonte D, Engelman JA, Watanabe G, Burk R, Pestell RG, Lisanti MP. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 1998 Nov 16;17(22):6633-48. PMID: 9822607 [PubMed - indexed for MEDLINE]

7: Watanabe G, Pena P, Shambaugh GE 3rd, Haines GK 3rd, Pestell RG. Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development. Brain Res Dev Brain Res. 1998 Jun 15;108(1-2):77-87. PMID: 9693786 [PubMed - indexed for MEDLINE]

8: Watanabe G, Albanese C, Lee RJ, Reutens A, Vairo G, Henglein B, Pestell RG. Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol Cell Biol. 1998 Jun;18(6):3212-22. PMID: 9584162 [PubMed - indexed for MEDLINE]

9: Watanabe G, Pena P, Albanese C, Wilsbacher LD, Young JB, Pestell RG. Adrenocorticotropin induction of stress-activated protein kinase in the adrenal cortex in vivo. J Biol Chem. 1997 Aug 8;272(32):20063-9. PMID: 9242678 [PubMed - indexed for MEDLINE]

10: Li X, Hales KH, Watanabe G, Lee RJ, Pestell RG, Hales DB. The effect of tumor necrosis factor-alpha and cAMP on induction of AP-1 activity in MA-10 tumor Leydig cells. Endocrine. 1997 Jun;6(3):317-24. PMID: 9368689 [PubMed - indexed for MEDLINE]

11: Xiong W, Pestell RG, Watanabe G, Li J, Rosner MR, Hershenson MB. Cyclin D1 is required for S phase traversal in bovine tracheal myocytes. Am J Physiol. 1997 Jun;272(6 Pt 1):L1205-10. PMID: 9227524 [PubMed - indexed for MEDLINE]

12: Watanabe G, Howe A, Lee RJ, Albanese C, Shu IW, Karnezis AN, Zon L, Kyriakis J, Rundell K, Pestell RG. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12861-6. PMID: 8917510 [PubMed - indexed for MEDLINE]

13: Pestell RG, Albanese C, Lee RJ, Watanabe G, Moran E, Johnson J, Jameson JL. A potential role for cell cycle control proteins in regulation of the cyclic adenosine 5'-monophosphate-responsive glycoprotein hormone alpha subunit gene. Cell Growth Differ. 1996 Oct;7(10):1337-44. PMID: 8891337 [PubMed - indexed for MEDLINE]

14: Watanabe G, Lee RJ, Albanese C, Rainey WE, Batlle D, Pestell RG. Angiotensin II activation of cyclin D1-dependent kinase activity. J Biol Chem. 1996 Sep 13;271(37):22570-7. PMID: 8798425 [PubMed - indexed for MEDLINE]

15: Pestell RG, Albanese C, Watanabe G, Lee RJ, Lastowiecki P, Zon L, Ostrowski M, Jameson JL. Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways. Mol Endocrinol. 1996 Sep;10(9):1084-94. PMID: 8885243 [PubMed - indexed for MEDLINE]

16: Shambaugh GE 3rd, Lee RJ, Watanabe G, Erfurth F, Karnezis AN, Koch AE, Haines GK 3rd, Halloran M, Brody BA, Pestell RG. Reduced cyclin D1 expression in the cerebella of nutritionally deprived rats correlates with developmental delay and decreased cellular DNA synthesis. J Neuropathol Exp Neurol. 1996 Sep;55(9):1009-20. PMID: 8800097 [PubMed - indexed for MEDLINE]

17: Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, Pestell RG. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem. 1995 Oct 6;270(40):23589-97. PMID: 7559524 [PubMed - indexed for MEDLINE]

18: Pestell RG, Albanese C, Watanabe G, Johnson J, Eklund N, Lastowiecki P, Jameson JL. Epidermal growth factor and c-Jun act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage (CYP11A1) promoter. J Biol Chem. 1995 Aug 4;270(31):18301-8. PMID: 7629150 [PubMed - indexed for MEDLINE]

19: Watanabe G, Ishiguro T, Miura H, Uemura K, Hiyoshi Y, Ozawa K, Nonogaki K, Tamagawa T, Sakamoto N, Iguchi A. CNS regulation of blood lactate concentration in anesthetized rats. Life Sci. 1994;54(20):1491-9. PMID: 7910651 [PubMed - indexed for MEDLINE]